When you need to tow and haul gargantuan payloads, there's no better choice than the Ford F-350. This heavy-duty pickup truck has all the right gear to get the job done. What's more is that it also gives you a spacious, comfortable cabin, modern safety equipment, and an impressive array of tech gadgets. If you're shopping for one, you might be wondering whether it's better to buy new or used. Don't worry - we're here to help. We've created this guide to help you go over some of the biggest differences between the 2010 and 2016 Ford F-350.